FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure
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FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure
Environmental factors such as nutritional state may act on the epigenome that consequently contributes to the metabolic adaptation of cells and the organisms. The lysine-specific demethylase-1 (LSD1) is a unique nuclear protein that utilizes flavin adenosine dinucleotide (FAD) as a cofactor. Here we show that LSD1 epigenetically regulates energy-expenditure genes in adipocytes depending on the ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2012
ISSN: 2041-1723
DOI: 10.1038/ncomms1755